Inflammation & Heart Disease

Inflammation & Heart Disease

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When we think of a heart, a cute little shape in red forms in our mind. But when it comes to the human heart, red is bad….

I have heard of other mesh women who died of a heart attack, so I decided to research to find out more, to see could implants be the problem. Then I found an amazing doctor ‘s article, who spoke out why current diets and treatments are not working and as always I will give you the link at the end of this blog.

We all know genetics and lifestyle can play a part in heart disease, but I wanted to learn if other things came into play. The reason I wanted to know, was because if there was anything women could do about their health, I wanted to learn and share the information. This is how his article begins.

Dr. Dwight Lundell

Prevent disease

Thu, 01 Mar 2012 21:58 UTC

We physicians with all our training, knowledge and authority often acquire a rather large ego that tends to make it difficult to admit we are wrong. So, here it is. I freely admit to being wrong. As a heart surgeon with 25 years experience, having performed over 5,000 open-heart surgeries, today is my day to right the wrong with medical and scientific fact.

I trained for many years with other prominent physicians labelled “opinion makers.” Bombarded with scientific literature, continually attending education seminars, we opinion makers insisted heart disease resulted from the simple fact of elevated blood cholesterol.

The only accepted therapy was prescribing medications to lower cholesterol and a diet that severely restricted fat intake. The latter of course we insisted would lower cholesterol and heart disease. Deviations from these recommendations were considered heresy and could quite possibly result in malpractice.

It Is Not Working!

I know what statins can do to someone and I have written about how they almost killed one of my sisters in England. There seems to be a ‘one treatment for all’ attitude by doctors and if you get sick from a drug, it’s just too bad. All they will do is suggest yet another dangerous drug. This is more of what this doctor said.

These recommendations are no longer scientifically or morally defensible. The discovery a few years ago, that inflammation in the artery wall is the real cause of heart disease is slowly leading to a paradigm shift in how heart disease and other chronic ailments will be treated.

Now if you read my blog about the immune disorders that can occur immediately after any implant, then you will know why inflammation is so important and why, if you are always ill, you need to find a way to travel to UCLA and get it removed. Here’s more.

Simply stated, without inflammation being present in the body, there is no way that cholesterol would accumulate in the wall of the blood vessel and cause heart disease and strokes. Without inflammation, cholesterol would move freely throughout the body as nature intended. It is inflammation that causes cholesterol to become trapped.

Inflammation is not complicated — it is quite simply your body’s natural defense to a foreign invader such as a bacteria, toxin or virus. The cycle of inflammation is perfect in how it protects your body from these bacterial and viral invaders. However, if we chronically expose the body to injury by toxins or foods the human body was never designed to process, a condition occurs called chronic inflammation. Chronic inflammation is just as harmful as acute inflammation is beneficial.

What thoughtful person would willfully expose himself repeatedly to foods or other substances that are known to cause injury to the body? Well, smokers perhaps, but at least they made that choice willfully.

The rest of us have simply followed the recommended mainstream diet that is low in fat and high in polyunsaturated fats and carbohydrates, not knowing we were causing repeated injury to our blood vessels. This repeated injury creates chronic inflammation leading to heart disease, stroke, diabetes and obesity.

So, did you think inflammation could cause many of your health problems? Read more.

Regardless of where the inflammatory process occurs, externally or internally, it is the same. I have peered inside thousands upon thousands of arteries. A diseased artery looks as if someone took a brush and scrubbed repeatedly against its wall. Several times a day, every day, the foods we eat create small injuries compounding into more injuries, causing the body to respond continuously and appropriately with inflammation.

So, all your diets and other ways you try to stay healthy, won’t work when there is inflammation present and you are at high risk for heart disease. Most of this article is about the foods we eat, but I am concentrating today on inflammation caused by foreign body reaction. The rest is up to you.

I kept digging to find out more about the inflammatory response of implants and found a good article about biomaterials/biological response. I know a lot of this report may go over your head, but you should recognize many words, because they are always written about foreign body reaction, especially that our implants are supposed to granulate to our tissues.

P1: FXY

May 18, 2001

19:17

Annual Reviews

AR132-04

BIOLOGICAL RESPONSES TO MATERIALS

83

In considering these early host reactions following injury, it is important to consider whether tissue resolution or organization occurs within the injured tissue or organ. In situations where injury has occurred and exudative inflammation is present, but no cellular necrosis or loss of basement membrane structures has occurred, the process of resolution occurs. Resolution is the restitution of the pre-existing architecture of the tissue or organ. On the other hand, with necro-sis, granulation tissue grows into the inflammatory exudate and the process of organization with development of fibrous tissue occurs. With implants, the process of organization with development of fibrous tissue leads to the well-known fibrous capsule formation at the tissue/material interface. The proliferative capacity of cells within the tissue or organ also plays a role in determining whether resolution or organization occurs. In general, the process of implantation in vascularized tissues leads to organization with fibrous tissue development and fibrous encapsulation.

Blood-Material Interactions and Initiation of the Inflammatory Response

Blood-material interactions and the inflammatory response are intimately linked and, in fact, early responses to injury involve mainly blood and the vasculature (1–4). Regardless of the tissue or organ into which a biomaterial is implanted, the initial inflammatory response is activated by injury to vascularized connective tissue (Table 2). Because blood and its components are involved in the initial inflammatory responses, thrombi and/or blood clots also form. Thrombus formation involves activation of the extrinsic and intrinsic coagulation systems, the complement system, the fibrinolytic system, the kinin-generating system, and platelets.

Thrombus or blood clot formation on the surface of a biomaterial is related to the well-known Vroman effect of protein adsorption. From a wound-healing perspective, blood protein deposition on a biomaterial surface is described as provisional

matrix formation.

Immediately following injury, changes occur in vascular flow, caliber, and permeability. Fluid, proteins, and blood cells escape from the vascular system into the injured tissue in a process called exudation. Following changes in the vascular system, which also include changes induced in blood and its components, cellular events occur and characterize the inflammatory response (3–6). The effect of the injury and/or biomaterial in situ on plasma or cells can produce chemical factors that mediate many of the vascular and cellular responses of inflammation.

Although injury initiates the inflammatory response, released chemicals from plasma, cells, and injured tissue mediate the response. Important classes of chemical mediators of inflammation are presented in Table 3. Several important points must be noted in order to understand the inflammatory response and how it relates to biomaterials.

Then there is more about implants and the inflammatory response.

Histological evaluation of tissue adjacent to implanted materials as a function of implant time has been the most commonly used method of evaluating the bio-compatibility. Classically, the biocompatibility of an implanted material has been described in terms of the morphological appearance of the inflammatory reaction to the material; however, the inflammatory response is a series of complex reactions involving various types of cells, the densities, activities, and functions of which are controlled by various endogenous and autocoid mediators. The simplistic view of the acute inflammatory response progressing to the chronic inflammatory response may be misleading with respect to biocompatibility studies and the inflammatory response to implants. Studies using the cage implant system show that monocytes and macrophages are present in highest concentrations when neutrophils are also at their highest concentrations, i.e. the acute inflammatory

response (21, 22). Neutrophils have short lifetimes—hours to days—and disappear from the exudate more rapidly than do macrophages, which have lifetimes of days to weeks to months.

Eventually macrophages become the predominant cell type in the exudate, resulting in a chronic inflammatory response. Monocytes rapidly differentiate into macrophages, the cells principally responsible for normal wound healing in the foreign body reaction. Classically, the development of granulation tissue has been considered to be a part of chronic inflammation,

but because of unique tissue-material interactions, it is preferable to differentiate the foreign body reaction—with its varying degree of granulation tissue development, including macrophages, fibroblasts, and capillary formation–from chronic inflammation.

So now my question to you is this. Did your implanting surgeon ever mention there could be a chronic inflammatory response to your implant? Believe me, mine certainly didn’t.

There is a lot more to this and I am giving you that link to read, so you can digest it slowly.

So, what if you are reading this and you are thinking OMG, I have heart disease and they put a stent in me, to help me. There are lawsuits on certain stents but you need to find out more about yours, by getting your hospital records from any surgery and find out if yours is one of the types that is cause for great concern. This is a study about drug-eluting heart stents.

What Randomized Trials Tell Us

Some have voiced concern that the trials leading to DES approval did not anticipate the broad adoption of these stents. Like most randomized trials, the approval studies that supported the safety and efficacy of DES enrolled a narrow population of patients undergoing single-vessel stenting in stable or unstable angina. However, numerous reports have since demonstrated the use of drug-eluting stents outside of the parameters tested in these trials (off-label use); these off-label uses represent about half of current practice.

Randomized trials are carefully designed experiments that vary only one condition between groups: the assigned treatment. It is appropriate that human studies begin within populations that are well-understood; in this case, it was a patient population that had been well-characterized in the era of bare-metal stents: those undergoing single-vessel treatment of de novo coronary stenosis. An attempt to include all patients in initial studies could have the unintended consequence of masking either benefit or harm by combining heterogeneous effects of treatment.

The deficits of this initial strategy are generalizability and power. Additional randomized trials may seek to address benefits and risks in some of the excluded subgroups or to define adjunctive therapy, but observational studies are necessary to understand the ultimate questions of risk and benefit across the full range of practice.

You will find out that studies aren’t always what they seem. Are these stents completely safe? Once again, it is all up to interpretation of doctors. Are they listening to patients about their symptoms? I doubt it.

Are Drug-Eluting Stents Getting a New Look?

Overall, although performed in different locations and with different methods, recent observational studies have shown reassuring results; in general, the prevention of restenosis promised by the randomized trials is evident in clinical practice and does not come at the expense of an increase in death or myocardial infarction compared with bare-metal stenting Although an early report from Sweden was a cause for alarm, the findings of increased late death associated with DES have been more recently reversed after more follow-up in the same study. The results from several other independent population-based studies across North America and Europe comparing the effect of DES on outcomes at 2 years have shown both no increase in death and preserved restenosis benefit.

So why are there lawsuits. You need to speak to a layer to find out more. In the meantime, this will explain the types of stents now on the market.

There are currently five types of stents available:

  • Dual Therapy Stent (DTS)
  • Bioresorbable Vascular Scaffold (BVS)
  • Bio-engineered Stent
  • Drug Eluting Stent (DES)
  • Bare Metal Stent (BMS)
  • Dual Therapy Stent
  • Dual Therapy Stent (DTS) is the latest type of coronary stent. It is a first-of-its-kind stent therapy designed to not only reduce the likelihood of the re-narrowing of the artery or of having to undergo a repeat procedure, but also help the healing process of the artery. It combines the benefit of DES and bio-engineered stents and is the only stent to contain a drug with active healing technology.
  • The DTS has coating both inside and outside, which reduces the likelihood of blood clots, inflammation and helps the healing process of the artery.
  • The stent surface facing the artery wall contains a drug that is released to help stop the artery blocking again without the worry of swelling or an inflammatory response. The drug is delivered from a bioresorbable polymer that will degrade over time.
  • The side of the stent which faces blood flow is coated with antibodies, which promote natural healing and helps the healthy artery function properly.

I am not giving you a link to find a lawyer, because I don’t work for any. All you have to do is Google one and call them, to find out more about heart stent lawsuits.

My whole problem with implants is that there are definitely foreign body reactions, and doctors are ignoring all the symptoms. Only you know if you began having heart disease symptoms after your implant, if you are a smoker or do other substances, that could affect your heart. I feel that the more we learn, the better we can take care of ourselves, and don’t let doctors run over us, with why we are sick.

Here are the links I promised.

Dr. Lundell’s article. https://www.sott.net/article/242516-Heart-surgeon-speaks-out-on-what-really-causes-heart-disease

This is the article about inflammatory response. https://www.bioen.utah.edu/faculty/pat/Courses/biomaterials/BiologicalResponse.pdf

This is about heart stents. http://circ.ahajournals.org/content/117/16/2047

Types of heart stents. https://www.orbusneich.com/en/patient/types-coronary-stents-0

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